- Chargé d’Affaires Daniel Rubinstein
- Deputy Chief of Mission Nicole Shampaine.

Daniel Rubinstein assumed responsibility as the Charge d’Affaires to the Arab Republic of Egypt on August 23, 2022. He served previously as Ambassador to Tunisia from 2015 to 2019.
Earlier, he served as Special Envoy for Syria; Principal Deputy Assistant Secretary of the Bureau of Intelligence and Research; Consul General and Chief of Mission in Jerusalem; Chief of the Civilian Observer Unit in the Multinational Force and Observers in Sinai, Egypt; and Deputy Chief of Mission in Amman.
Ambassador Rubinstein is a graduate of the University of California, Berkeley. He is fluent in Arabic.